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E
2
1,25D
1,25D
1,25D
VDRE
VDRE
ERE
ESR1/2
GPER
ESR1/2
VDR
mem
VDR
nuc
Calcium
uptake
VDR gene
VDR protein
ERα gene
ERα protein
Cyp19 gene
Testosterone
production
Aromatase
activity
E
2
, production
Cytoplasm
Nucleus
Target cell
+
+
+
+
+
+/-
+/-
work
by sam
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