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Novel pathophysiologic insight into HF

HFpEF
Exercise intolerance +
↑↑PCWP during exercise
Impaired splanchnic vasoconstriction?
Dependent on splanchnic vasoconstriction to ↑CO?
Ideal candidate for GSN ablation (responders)
STOP
Yes
No
Yes
No

LH, dizzy or can't tolerate preload reduction

Orthostatic hypotension

PP decreases upon standing

Stiff LV or RV, LA or RA failure, ↑↑PVR, or inability to ↑HR

Inability to augment CO with exercise

NOVEL PATHWAYS

by H

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