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Multiple Liver Injuries
Alcohol, Cytokines, PDGF, TGF-β, TNF-α, IL-1
Hypoxia
Kupffer Cells Activation
LSECs Activation
Hepatocytes Damage
HSC Activation
Proliferation, Migration Myofibroblast transformation
ECM/Collagen Production
FIBROSIS/CIRRHOSIS
patho
by pharma
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