CRH

Pituitary gland

ACTH

β-Endorphin

Adrenal Cortex

Cortisol

GPx

SOD

CAT

NPY sub. P

+ GPCR

↓ Protein kinase

↓ cAMP

↓ Ca2+ f

↓ pain

↓ ACTH

↓ Cortisol

↓ NFkB

Mitochondrial dysfunction

ROS

↑ Blood glucose

GPx

SOD

CAT

ROS

Misfolded protein

HSP70