Causes of Chronic DiarrheaDifferential Diagnosis

Inflammatory Causes

Infectious

Non-infectious

Viral: AIDS enteritis, CMV

Mycobacterial: Tuberculosis, MAC

Inflammatory bowel disease (IBD): Ulcerative colitis, Crohn's disease

Radiation enteritis/proctitis

Non-Inflammatory Causes

Osmotic

Secretory

Malabsorptive

Hypermotility

Food/Drink: Lactose intolerance, Artificial sweeteners (sorbitol, high fructose corn syrup)

Medications: Acarbose, Mg hydroxide, Lactulose

Laxative abuse

Microscopic colitis

Medications: NSAIDs, Colchicine

Neuroendocrine tumors: Carcinoid syndrome, Gastrinoma (ZE syndrome)

Celiac disease (a.k.a. "celiac sprue")

Pancreatic insufficiency: Chronic pancreatitis, Cystic fibrosis

Tropical sprue

Medications ("drug-induced enteropathy"): Olmesartan

Irritable bowel syndrome (IBS)

Hyperthyroidism

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