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INTERLEUKIN-1
Macrophages and many others
PROMOTES INFLAMMATION


Collagen synthesis

Chondrocyte activity

Fibroblast activity

Bone resorption

AFFECTS LEUKOCYTES


Th2 cell cytokine production

Eosinophil degranulation

Basophil degranulation

KILLS CELLS


Tumor cells

AFFECTS THE BRAIN


Fever

Drowsiness

Loss of appetite

Malaise

AFFECTS METABOLISM


Mucus production

Lipoprotein lipase

Acute-phase protein synthesis

Mobilizes amino acids

AFFECTS BLOOD FLOW


IFN-γ synthesis

Integrin expression

AFFECTS CELL GROWTH


Fibroblasts

Keratinocytes

Mesangial cells

Glial cells

Vascular smooth muscle

Interleukin-1

by Zilly

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