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Neurology — Epilepsy (Adults, Pediatrics, Pregnancy)


Drug Class Uses Side effects Contraindications Notes

Valproate (Valproic acid) Broad-spectrum ASD Generalized & absence seizures; Status epilepticus (step-3) Teratogenic (neural-tube defects) Pregnancy / women of child-bearing potential Prefer lamotrigine/levetiracetam in young women; if already pregnant: don’t stop abruptly; plan switch before conception.

Lamotrigine ASD / mood stabilizer First-line monotherapy; Absence (with valproate); Safer in pregnancy/elderly Not specified in lecture (adult deck: rash mentioned) Not specified Monitor levels during pregnancy; post-partum readjust dose.

Levetiracetam ASD First-line; Status step-3 alternative Not specified Not specified Fewer interactions; rapid titration; acceptable in pregnancy.

Oxcarbazepine ASD First choice for focal/partial Hyponatremia Not specified Reasonable in elderly; option in pregnancy.

Carbamazepine ASD / mood stabilizer First choice for focal/partial; listed for mania Not specified Not specified Therapeutic level (mania): 6–12 mg/L.

Ethosuximide ASD Childhood absence (first-line); adult absence (2nd-line) Not specified Not specified

Topiramate ASD / adjunct in mania Add-on/LGS Not specified Not specified

Phenytoin ASD Conventional; previously status step-3 (now less preferred) Many interactions; cardiac effects/arrhythmias Not specified Replaced by valproate/levetiracetam for status.

Phenobarbital ASD Conventional; neonatal use Not specified Not specified

Gabapentin ASD Adjunct in elderly partial-onset; listed among mania agents Not specified Not specified

Thiopental IV anesthetic Refractory status epilepticus (ICU) Not specified Not specified Use with ventilatory support.

Propofol IV anesthetic Refractory status epilepticus (ICU) Not specified Not specified

Lorazepam (IV) Benzodiazepine >5 min seizure termination; acute febrile seizures Not specified Not specified

Midazolam (buccal) Benzodiazepine As above (community/ED) Not specified Not specified

Diazepam (rectal) Benzodiazepine As above (home/ED); rectal in pediatrics Can ↑ disorientation; paradoxical agitation (delirium deck) Not specified See delirium note; route for febrile seizures.

Antipyretics (class) Analgesic/antipyretic Comfort only in febrile seizures Not specified Not specified Do not prevent seizures.

Folic acid (5 mg/d) Vitamin Pre-conception for women with epilepsy Not specified Not specified Start ≥3 months before conception.

Neurology — Multiple Sclerosis


Drug Class Uses Side effects Contraindications Notes

Methylprednisolone (IV 500–1000 mg ×3–5d) Corticosteroid Acute relapse GI upset/gastritis, ↑glucose/↑BP, depression, osteoporosis; insomnia, weight gain Not specified Start early after relapse; write drug by name.

Interferon-β Immunomodulator (inj.) DMT to reduce relapses Flu-like sx, pain, skin rxns, depression Pregnancy (slide: abortion/teratogenic) SC 1–3×/wk.

Glatiramer acetate Immunomodulator (inj.) DMT Not specified — Allowed in pregnancy (only one noted).

Fingolimod S1P modulator (oral) DMT Not specified Pregnancy (very teratogenic) Washout ~2 months pre-conception.

Teriflunomide Pyrimidine-synthesis inhibitor (oral) DMT Not specified Pregnancy (teratogenic) Requires washout (duration not specified on slide).

Dimethyl fumarate Oral fumarate DMT Not specified Not specified Oral option.

Natalizumab α4-integrin inhibitor (IV) DMT Not specified Not specified Monthly IV.

Alemtuzumab Anti-CD52 mAb (IV) DMT (advanced) Not specified Not specified Infusion option.

Ofatumumab Anti-CD20 mAb (SC monthly) DMT “No major side effects highlighted” Not specified “Most used now; effective & safer; easy to inject.”

Ocrelizumab Anti-CD20 mAb (IV q6mo) DMT “No major side effects highlighted” Not specified “Major shift in MS management.”

High-efficacy DMTs (Natalizumab/Ofatumumab/Ocrelizumab/Rituximab) Biologics Pregnancy planning: stop before; if pregnant on therapy—may continue with caution Not specified Not specified Timing-critical on slide.

SSRIs (class) Antidepressants Depression in MS Not specified Not specified Symptomatic management.

Analgesics (class) Analgesic Pain/headache in MS Not specified Not specified Symptomatic.

Sleep Disorders — Narcolepsy & Cataplexy


Drug Class Uses Side effects Contraindications Notes

Modafinil (Vigil) Wakefulness-promoting Daytime somnolence in narcolepsy Not specified in lecture Not specified From “Sleep Disorders” slide (image you sent).

Sodium oxybate CNS agent Cataplexy in narcolepsy Not specified Not specified As listed on the slide.

Antidepressants (class) — Cataplexy (selected agents) Not specified Not specified “Certain antidepressants” (names not given).

Neuro-ophthalmology — Pupil & Strabismus

Drug Class Uses Side effects Contraindications Notes

Cocaine (topical) Indirect sympathomimetic Historic Horner test (normal dilates; Horner doesn’t) Not specified Not specified Mechanism: blocks NE reuptake; physiologic anisocoria → both dilate.

Phenylephrine 10% Direct sympathomimetic Horner (denervation hypersensitivity) / mechanical miosis doubt Not specified Not specified Dilates Horner pupil more than normal.

Apraclonidine α2-agonist (weak α1) Current test to confirm Horner Not specified Not specified Replaced cocaine test in practice.

Hydroxyamphetamine Indirect sympathomimetic Localize Horner (pre- vs post-ganglionic) Not specified Not specified Stimulates NE release.

Pilocarpine 0.1% Parasympathomimetic Adie (tonic) pupil test—constricts abnormal pupil Not specified Not specified Denervation supersensitivity.

Pilocarpine 1–2% Miotic 3rd-nerve vs pharmacologic mydriasis Not specified Not specified Palsy pupil constricts; drug-dilated does not.

Atropine / Tropicamide Mydriatic/cycloplegic Pharmacologic dilation (anisocoria differential) Not specified Not specified

Morphine Opioid Cause of pin-point pupils (coma context) Not specified Not specified

Botulinum toxin (Botox) Chemodenervating Strabismus (temporarily weaken EOM); Hoarseness selected cases; Spasmodic dysphonia Not specified Not specified Multiple lectures mention (strabismus, hoarseness, phonetics).

Psychiatry — Antidepressants & Anxiolytics


Drug/Group Class Uses Side effects Contraindications Notes

Fluoxetine / Sertraline / Paroxetine / Citalopram SSRIs MDD, GAD, PTSD, panic/phobic, OCD, bulimia, atypical depression; anxiety in medical pts; comorbid depression in MS; somatoform contexts Anorexia, nausea, insomnia, ↓libido, SIADH, bruxism; suicidality (young) Avoid with MAOIs Sertraline safest post-MI; mainstay in anxiety (with CBT).

Amitriptyline / Imipramine / Clomipramine TCAs MDD; neuropathic pain; migraine; OCD (clomipramine); nocturnal enuresis (imipramine); somatoform (pain/hypochondriasis with SSRIs) Antimuscarinic effects; orthostasis; sedation; seizure risk BPH, angle-closure glaucoma

Venlafaxine / Duloxetine SNRIs Mixed 5-HT/NA reuptake inhibitor class for depression/anxiety spectrum Not specified Not specified Named as “newer mixed reuptake inhibitors.”

Bupropion NDRI Depression; smoking cessation Tachycardia, insomnia, headache; seizures in bulimia/anorexia Bulimia or anorexia nervosa Lower sexual/weight AEs.

Mirtazapine NaSSA Depression with insomnia/weight loss Sedation; ↑appetite/weight; dry mouth Not specified α2-blocker; 5-HT2/5-HT3 & H1 block.

Trazodone SARI Sedating option for insomnia/anorexia Not specified Not specified

Propranolol (low dose) β-blocker Anticipated triggers (social phobia) 15–30 min before event Not specified Not specified Event-only, not daily.

Benzodiazepines Anxiolytics Short-term adjunct in anxiety; max ~1 month to avoid dependence; not routine in delirium (except alcohol-withdrawal) Addiction/dependence risk; may ↑ disorientation & paradoxical agitation Not specified Combine with CBT; avoid daytime sedatives in delirium.

Psychiatry — Psychosis / Mania (incl. EPS tools)


Drug Class Uses Side effects Contraindications Notes

Haloperidol Typical (high-potency) Psychosis; drug of choice in delirium; acute mania (with mood stabilizer) EPS Not specified

Fluphenazine / Pimozide Typical (high-potency) Psychosis EPS Not specified

Chlorpromazine / Thioridazine Typical (low-potency) Psychosis Cardiotoxic & anticholinergic profile; sedation, hypotension Not specified

Risperidone Atypical Psychosis; acute mania Dose-dependent EPS; hyperprolactinemia; weight gain; sedation Not specified Behaves like typical >6 mg.

Olanzapine Atypical Psychosis; acute mania Marked weight gain; ↑ lipids/glucose; ↑ LFTs Obesity/DM/↑chol (slide: “contraindicated”) Highest metabolic risk.

Quetiapine Atypical Psychosis ↑ LFTs (~6%); weight gain < olanzapine; metabolic effects (less); orthostasis Not specified Start low in elderly.

Ziprasidone Atypical Psychosis QT prolongation; hyperprolactinemia (< risperidone) Avoid in heart disease No weight gain; absorption ↑ with food.

Aripiprazole Atypical (D2 partial agonist) Psychosis Low EPS/sedation; akathisia/activation Not specified Interactions: ↑ by fluoxetine/paroxetine; ↓ by carbamazepine; ↑ by ketoconazole.

Clozapine Atypical TRS Agranulocytosis (monitor WBC); ↑ seizures (esp. + lithium); heavy metabolic AEs Not specified Not first-line.

Benztropine / Trihexyphenidyl / Diphenhydramine Anticholinergics Treat EPS (dystonia, parkinsonism) Anticholinergic AEs Not specified Caution with other anticholinergics (e.g., TCAs).

Amantadine Dopamine facilitator Helps EPS Not specified Not specified

Propranolol β-blocker Akathisia adjunct Not specified Not specified

Delirium


Drug Class Uses Side effects Contraindications Notes

Haloperidol Typical antipsychotic Drug of choice for delirium Not specified Not specified Keep meds minimal; avoid daytime sedatives.

Diazepam (class: benzodiazepines) Benzodiazepine Reserve for alcohol-withdrawal delirium; short-term sleep only in select pts ↑ disorientation; paradoxical agitation Not specified

CNS Infections


Drug Class Uses Side effects Contraindications Notes

Ceftriaxone + Vancomycin 3rd-gen ceph + glycopeptide Empiric acute bacterial meningitis Not specified Not specified Start ASAP (after bloods/LP), then tailor.

Dexamethasone Corticosteroid Adjunct in bacterial meningitis Not specified Not specified Case-by-case.

Acyclovir (IV) Antiviral HSV encephalitis/viral meningitis; part of initial triple when unclear Not specified Not specified Start early; ~10–14 d.

AEDs (class) Anticonvulsants Seizure control in encephalitis Not specified Not specified

Corticosteroids (class) Anti-edema Cerebral edema in encephalitis Not specified Not specified

Rifampin / Ciprofloxacin / Ceftriaxone Antibiotics Chemoprophylaxis for meningococcal contacts Not specified Not specified Plus isolation 24h after antibiotics; vaccinate as indicated.

Doxycycline / Cefuroxime Antibiotics Lyme disease Not specified Not specified

Meningococcal vaccine Vaccine Scheduled/booster in context Not specified Not specified

Antibiotics (class) Antibacterial Brain abscess (± neurosurgical drainage) Not specified Not specified

ENT — Nasal / Polyps / Sinusitis


Drug Class Uses Side effects Contraindications Notes

Desloratadine / Levocetirizine Oral antihistamine Allergic rhinitis (mild–moderate) Not specified Not specified Add eye drops if ocular sx.

Azelastine (nasal) Topical antihistamine Allergic rhinitis Not specified Not specified

Mometasone / Fluticasone (nasal) Topical corticosteroid AR; polyps (first-choice) “Generally safe” (topical) Not specified

Prednisolone (oral) Systemic steroid Polyps (short taper post-op) Systemic AEs: Cushing’s, DM, HTN, cataracts, hypothyroidism (listed) Not specified Taper ~3 weeks.

Xylometazoline (Otrivin) Topical decongestant Severe obstruction (brief use) Not specified Not specified Short courses only.

Leukotriene receptor antagonists Class Polyps (allergy-related) Not specified Not specified

Amoxicillin-clavulanate Antibiotic Polyps with sinusitis/obstruction; acute bacterial sinusitis Not specified Not specified

Secretolytic agents Mucolytics Acute sinusitis Not specified Not specified

Antibiotics / Oral corticosteroids (class) — Acute sinusitis (selected cases) Not specified Not specified

Silver nitrate Chemical cautery Minor/recurrent epistaxis Not specified Not specified

ENT — Larynx & Hoarseness


Drug Class Uses Side effects Contraindications Notes

Racemic epinephrine (neb.) Sympathomimetic Croup Not specified Not specified Vasoconstriction → ↓edema → better breathing.

Corticosteroids (systemic) Anti-inflammatory Croup; Acute epiglottitis (with IV antibiotics); some hoarseness cases Not specified Not specified Not useful in Reinke’s edema (surgery instead).

Antibiotics (IV) Antibacterial Acute epiglottitis Not specified Not specified Secure airway first.

Anti-reflux meds Anti-reflux therapy GERD/LPR-related hoarseness; post-op after microlaryngeal surgery Not specified Not specified First choice on Tx slide.

Botulinum toxin (BOTOX) Chemodenervating Selected hoarseness cases; spasmodic dysphonia Not specified Not specified Also used in strabismus.

Inhaled corticosteroids / Hormone therapy / Antipsychotics / Thrombolytics — (causes) — Listed as drug causes of hoarseness — Take careful drug history.

ENT — Adenoid & Tonsils / Swallowing


Drug Class Uses Side effects Contraindications Notes

Saline nasal irrigation Topical saline Adenoid symptoms Not specified Not specified Conservative.

Antihistamines Class Add if co-existing allergy (adenoid) Not specified Not specified

Antibiotics (class) Antibacterial Bacterial adenoiditis; acute tonsillitis/sinusitis (as indicated) Not specified Not specified

Penicillin (7–10 d) β-lactam Acute tonsillitis—DOC Not specified Penicillin allergy If allergic → macrolide.

Macrolides Antibiotic class Acute tonsillitis (penicillin-allergic) Not specified Not specified

Analgesics/Antipyretics — Symptom control (tonsillitis) Not specified Not specified Include salt-water gargles.

Barium sulfate Contrast Barium swallow (diagnosis) Not specified Not specified For Zenker/achalasia evaluation.

Neurology — Facial Nerve Palsy (Bell’s & Secondary)


Drug Class Uses Side effects Contraindications Notes

Prednisone (oral) Corticosteroid Bell’s palsy Not specified Not specified Always add PPI; with eye care.

PPI (e.g., omeprazole) PPI Gastric protection with steroid Not specified Not specified “Rule until you retire.”

Artificial tears (± patch) Ocular lubricant Corneal protection Not specified Not specified Part of basic care.

Valacyclovir Antiviral Add-on in severe cases (esp. immunosuppressed) Not specified Not specified 1 week; evidence unproved.

Antibiotics (class) Antibacterial Secondary FNP (otitis/skull-base infection) Not specified Not specified Treat cause.

Cephalosporins / LMWH dextran — — — — Least effective options in MCQs for idiopathic Bell’s.

Neurodevelopmental — ADHD / ASD (Adults)


Drug Class Uses Side effects Contraindications Notes

Methylphenidate / Dextro-amphetamine Psychostimulants ADHD (adults); also when ASD + ADHD Not specified Not specified Combined therapy > meds alone > therapy alone.

Atomoxetine SNARI ADHD Not specified Not specified Non-stimulant option.

SSRIs (class) Antidepressants ASD: comorbidities & repetitive/obsessive behaviors Not specified Not specified Not for core social deficits.

Antipsychotics (class) Antipsychotics ASD: aggression, tantrums, stereotypies, self-injury Not specified Not specified

Melatonin Sleep regulator Sleep problems in ASD Not specified Not specified

Somatoform / Medically Unexplained Physical Symptoms


Drug Class Uses Side effects Contraindications Notes

SSRIs Antidepressants Body dysmorphic disorder; Hypochondriasis (with TCAs); treat comorbid anxiety/depression/sleep disturbance Not specified Not specified Lecture states no specific medicine for somatoform d/o overall.

TCAs Antidepressants Pain symptoms; Hypochondriasis (with SSRIs) Not specified Not specified Use as adjunct only.

General Hospital Psychiatry (med effects)


Drug Class Uses Side effects Contraindications Notes

SSRIs Antidepressants Depression/anxiety in medically ill Not specified Not specified With CBT & self-care.

Benzodiazepines Anxiolytics Short-term for anxiety Not specified Not specified

Corticosteroids (long-term) Steroids — May precipitate mania/schizophrenia Not specified Medical tx that can cause psychiatric sx.

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