Neurology — Epilepsy (Adults, Pediatrics, Pregnancy)
Drug Class Uses Side effects Contraindications Notes
Valproate (Valproic acid) Broad-spectrum ASD Generalized & absence seizures; Status epilepticus (step-3) Teratogenic (neural-tube defects) Pregnancy / women of child-bearing potential Prefer lamotrigine/levetiracetam in young women; if already pregnant: don’t stop abruptly; plan switch before conception.
Lamotrigine ASD / mood stabilizer First-line monotherapy; Absence (with valproate); Safer in pregnancy/elderly Not specified in lecture (adult deck: rash mentioned) Not specified Monitor levels during pregnancy; post-partum readjust dose.
Levetiracetam ASD First-line; Status step-3 alternative Not specified Not specified Fewer interactions; rapid titration; acceptable in pregnancy.
Oxcarbazepine ASD First choice for focal/partial Hyponatremia Not specified Reasonable in elderly; option in pregnancy.
Carbamazepine ASD / mood stabilizer First choice for focal/partial; listed for mania Not specified Not specified Therapeutic level (mania): 6–12 mg/L.
Ethosuximide ASD Childhood absence (first-line); adult absence (2nd-line) Not specified Not specified
Topiramate ASD / adjunct in mania Add-on/LGS Not specified Not specified
Phenytoin ASD Conventional; previously status step-3 (now less preferred) Many interactions; cardiac effects/arrhythmias Not specified Replaced by valproate/levetiracetam for status.
Phenobarbital ASD Conventional; neonatal use Not specified Not specified
Gabapentin ASD Adjunct in elderly partial-onset; listed among mania agents Not specified Not specified
Thiopental IV anesthetic Refractory status epilepticus (ICU) Not specified Not specified Use with ventilatory support.
Propofol IV anesthetic Refractory status epilepticus (ICU) Not specified Not specified
Lorazepam (IV) Benzodiazepine >5 min seizure termination; acute febrile seizures Not specified Not specified
Midazolam (buccal) Benzodiazepine As above (community/ED) Not specified Not specified
Diazepam (rectal) Benzodiazepine As above (home/ED); rectal in pediatrics Can ↑ disorientation; paradoxical agitation (delirium deck) Not specified See delirium note; route for febrile seizures.
Antipyretics (class) Analgesic/antipyretic Comfort only in febrile seizures Not specified Not specified Do not prevent seizures.
Folic acid (5 mg/d) Vitamin Pre-conception for women with epilepsy Not specified Not specified Start ≥3 months before conception.