Shows pronounced hyperplasia of both connective tissue and epithelium.

Overall, the lesion represents an overgrowth due to increased cell number and matrix production.

Acanthosis (thickening) of the epithelial layer.

Elongated rete pegs extend deep into the connective tissue.

In cyclosporine-induced enlargements, structural changes occur in the outer epithelial cell surface.

Densely arranged collagen bundles.

Increased fibroblast number (suggesting active proliferation).

Increased new blood vessel formation (angiogenesis).

Abundance of amorphous ground substance (non-fibrous matrix material).

Enlargement begins as hyperplasia in the connective tissue core of the marginal gingiva.

Progresses by proliferation and expansion beyond the crest of the gingival margin.

More vascularized connective tissue.

Presence of foci of chronic inflammatory cells, particularly plasma cells.

The mature lesion shows a fibroblast-to-collagen ratio similar to normal gingiva.

Indicates that earlier in development, there was an abnormally high fibroblast proliferation.

Numerous oxytalan fibers seen beneath the epithelium and in inflamed areas.

Inflammation commonly seen along sulcular (pocket-lining) surfaces.

Show granulation tissue composed of:

Numerous young capillaries

Fibroblasts

Irregularly arranged collagen fibrils

Occasional lymphocytes