Retrieval-Augmented Generation • PI-RADS v2.1 (ACR, 2019) • NCCN Guidelines

Instruction Tuning • Medical QA datasets (Peng et al., 2023)

Constraint Rules • Reject PI-RADS 6 • Valid Gleason range

Fine-Tuned GPT-4 Clinical Embedding Space

Radiologist Report • Structured findings • NCCN-aligned recs

Patient Summary • Grade 6 readability • Risk visualization

Clinical Decisions • JSON-structured • Urgency flags

Radiologist Review • Error correction • Priority tagging

SHAP Explainability • Top 3 risk factors (Lundberg & Lee, 2017)

Federated Learning • Differential privacy (Abadi et al., 2016)

MRI Imaging • PI-RADS • ADC values • Tumor volume

Histopathology • Gleason score • PNI status • Core involvement

Family History • Affected relatives • BRCA2/HOXB13

Demographics • Age/Race • Comorbidities

Lab Data • PSA velocity • PSA density

Data Fusion